Review on Population Pharmacokinetics of Amikacin in Paediatrics

Amikacin is an aminoglycoside antibiotic with a broad-spectrum bacterial coverage that frequently utilized both as monotherapy and in combination other antibiotics for severe infections the paediatric population. The narrow therapeutic index of drug high inter-individual variabilities exposure results either toxicity or subtherapeutic concentrations. Thus, monitoring population pharmacokinetics are pivotal to facilitate optimal dosage regimens paediatrics negate adverse outcomes. goal maintain target peak trough concentrations within 30-40mg/l <5 mg/l respectively. This review aimed summarize pharmacokinetic considerations parameters amikacin across